CEOLUS™
MCC as Pharmaceutical Excipient for Drug Formulation
Microcrystalline Cellulose (MCC) is purified, partially depolymerized cellulose used by pharmaceutical customers around the world, CEOLUS™ offers superior performance and quality based on advanced particle design, production, and processing technologies at Asahi Kasei.
Asahi Kasei started MCC production in 1970. Since the 2000s, Asahi Kasei has been continuously developing MCC products that have unique performance which derives from our patented unique morphology design. The products have helped customers with technical challenges among several product development stages such as lab, scale-up, and production.
Asahi Kasei’s high functional excipients, CEOLUS™ KG & CEOLUS™ UF grades are distinct in terms of its application & provide greater flexibility to a scientist in designing a formulation. The high functional excipients also solve a range of tableting related issues namely capping, sticking & others. Other high functional excipients include MCC spheres CELPHERE™ used for drug layering and Pregelatinized corn starch PC-10.
Products Line-up
| Grade | Features | Performance | Benefits for Customers |
|---|---|---|---|
| CEOLUS™ KG |
Rod-shaped particles | Super-compactability MCC | Facilitate high-dose formulation Realize low pressure tableting Lower tablet friability Preventing sticking and capping Suitable for roller compaction Suitable for ODT, bilayer tablets, MUPS tablets |
| CEOLUS™ UF-702 |
Round shaped and Porous MCC particle |
Super-flowability Swellability Adsorption on the particle surface |
Improve poorly flowable formulations Fast disintegration and dissolution with sufficient hardness Prevent segregation and over-lubrication Facilitate high speed tableting |
| CEOLUS™ UF-711 |
Porous MCC particle |
Well-balanced compactability and flowability | Optimized for tableting of poorly compactable and flowable formulations |
| CELPHERE™ | 100% MCC sphere Smooth surface Excellent sphericity Narrow size distribution |
High Mechanical strength Moderate water absorption Low reactivity Stable particle property |
Tolerant with high stress and coating machine varieties Reduce aggregation Yield improvement in coating Stable storage stability Suitable for controlled released formulations like MUPS |
| PC-10 | Partly pregelatinized starch with outer shell structure | High water retention capacity Lower water-soluble content pH independent disintegration Low reactivity |
Toler-Stabilizer for moisture sensitive API Granulation aid Carrier for extracts Dissolution enhancer |
CEOLUS™ KG
KG grade is fibrous morphology in nature with high L/D ratio and specialized in the performance of compactibility. It undergoes plastic deformation helping to eliminate Capping & Sticking issue.
CEOLUS™ UF
UF grade is round shaped porous morphology creating a rough surface and superior in both flowability and compactibility, thus providing superior adsorption property eliminating segregation.
CELPHERE™
CELPHERE™ is 100% MCC spherical seed core. It’s tolerant to high stress and coating machine varieties solving issues like crushing and aggregation of pellets.
FAQ
(1) What is the difference between alpha form MCC and beta form MCC?
MCC is made from alpha cellulose. Normally it is regarded as “alpha” form. “Beta form” is used to explain a needle shape particle morphology of MCC in order to differentiate it from conventional MCC in a certain situation.
(2) Are CEOLUS™ grades patented?
Yes, CEOLUS™ UF & KG grades are patented
(3) Where is production site of CEOLUS™?
Asahi Kasei currently manufactures CEOLUS™ in Miyazaki, Japan, and will build a second plant in Okayama, Japan.
